American scientists have shown in mouse models of osteoporosis that low doses of aspirin may inhibit osteoklasty and activate osteoblasty, according to a report published in the online journal "PLoS (Public Library of Science) One".
Although aware that the accelerated bone resorption osteoklastami is the "primary mechanism underlying osteoporosis, recent experimental data allowed to assume that the discrepancy apoptosis osteoblastov number osteotsits, at least partly cause imbalance remodeling bone tissue, which occurred in osteoporosis", - note Dr. Songtao Shi (Songtao Shi) (University of Southern California (USC) School of Dentistry, Los Angeles), and colleagues.
The authors also noted that the studies in vitro aspirin may inhibit activation of T-cells and Fas-induced apoptosis ligand BMMSC. Further examination showed that in mouse models of osteoporosis caused by ovarektomia, adding low doses of aspirin increases osteogenesis BMMSCs osteoklasts and inhibits the activity, resulting in an increase in bone density.
"Farmakological regulation BMMSCs aspirin could become a new approach for treating estrogen-scarce osteoporosis", - the scientists conclude.
Although epidemiological studies suggested that regular use of aspirin has a moderate favourable effect on bone mineral density in women in postmenopause, "requires more detailed study to explain the main mechanism by which aspirin could prevent and treat osteoporosis", - Dr. Shi added.
Although aware that the accelerated bone resorption osteoklastami is the "primary mechanism underlying osteoporosis, recent experimental data allowed to assume that the discrepancy apoptosis osteoblastov number osteotsits, at least partly cause imbalance remodeling bone tissue, which occurred in osteoporosis", - note Dr. Songtao Shi (Songtao Shi) (University of Southern California (USC) School of Dentistry, Los Angeles), and colleagues.
"Initially, we found that activated T-cells can damage the mezenhimalnyh bone marrow stem cells (BMMSCs) - progenitorns cells forming bone osteoblasts - through a specific path of death of cells (Fas / Fas ligand) in mice with osteoporosis", - said Dr. Shi.
This finding suggests that osteoporosis "can be caused by two factors, one of which - previously identified active resorption, and another - recently identified lack of BMMSC" - explains the scientist.
The authors also noted that the studies in vitro aspirin may inhibit activation of T-cells and Fas-induced apoptosis ligand BMMSC. Further examination showed that in mouse models of osteoporosis caused by ovarektomia, adding low doses of aspirin increases osteogenesis BMMSCs osteoklasts and inhibits the activity, resulting in an increase in bone density.
"Farmakological regulation BMMSCs aspirin could become a new approach for treating estrogen-scarce osteoporosis", - the scientists conclude.
Although epidemiological studies suggested that regular use of aspirin has a moderate favourable effect on bone mineral density in women in postmenopause, "requires more detailed study to explain the main mechanism by which aspirin could prevent and treat osteoporosis", - Dr. Shi added.
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